Phase Transitions in the Multi-cellular Regulatory Behavior of Pancreatic Islet Excitability
نویسندگان
چکیده
منابع مشابه
Phase Transitions in the Multi-cellular Regulatory Behavior of Pancreatic Islet Excitability
The pancreatic islets of Langerhans are multicellular micro-organs integral to maintaining glucose homeostasis through secretion of the hormone insulin. β-cells within the islet exist as a highly coupled electrical network which coordinates electrical activity and insulin release at high glucose, but leads to global suppression at basal glucose. Despite its importance, how network dynamics gene...
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ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2014
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1003819